The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
Participants will have a single sample (8-10 teaspoons) of blood collected at M. D.
Anderson, depending upon current health status. If participant unable or unwilling to give
a blood sample, saliva samples can be collected instead.
Participants will be asked to answer a series of questions. These questions will ask about
foods eaten either one year ago or one year before the first diagnosis of cancer. There
will also be questions about cooking methods as well as overall health, and vitamin and
medication use. Some of the questions are personal, but all answers will be kept strictly
private. The questionnaire will be sent to homes via U.S. or express mail. It may take
several hours to complete the survey, but there is no time limit on its completion.
Solid tumor material and colonoscopy specimens of normal tissue will be collected from
participants requiring either colonoscopy or surgery for routine clinical reasons. The
tumor fragments will be collected from specimens. Tissue required for a clinical pathology
diagnosis will not be used for research purposes.
About 2,000 patients and family members will take part in this study. All will be enrolled
at M. D. Anderson.
Observational Model: Family-Based, Time Perspective: Prospective
Time to Onset for Colorectal Cancer
Primary endpoint is time to onset for colorectal cancer using Cox proportional hazard regression for determining the role that polymorphic variants of genes have on risk for development of HNPCC at an early age.
Overall study period up to 15 years.
Patrick Lynch, MD, JD
UT MD Anderson Cancer Center
United States: Institutional Review Board
|UT MD Anderson Cancer Center||Houston, Texas 77030|