Prevention of Blood Transfusion With Intravenous Iron in Gynecologic Cancer Patients Receiving Platinum Based Chemotherapy
Anemia is a common condition during chemotherapy administration. Treatment options usually
include oral iron supplementation and blood transfusion. However, oral iron has
gastrointestinal side effects, which affects patient compliance, and only a small amount of
oral iron can be absorbed from the gastrointestinal tract. Intravenous iron may overcome a
block of iron absorption and iron recycling induced by hepcidin. Therefore, it may increase
hemoglobin level and reduced blood transfusion in cancer patients receiving chemotherapy.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Red blood cell (RBC) transfusion rate
The requirement of red blood cell transfusion before administration of chemotherapy will be evaluated for 6 cycles of chemotherapy.
Tarinee Manchana, MD
Thailand: Ethical Committee
IV iron 2