S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML
OBJECTIVES:
- To identify differentially methylated regions (DMRs) associated with overall survival
(OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.
- To develop and evaluate in an independent validation set a prognostic score for OS
based on the identified DMR.
- To determine whether the prognostic score can group patients into risk groups based on
OS.
OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations
by CHARM array-based genome assay. Each patient's clinical data is also collected.
Observational
Time Perspective: Retrospective
Identification of DMRs associated with OS
immediate
No
Min Fang, MD, PhD
Principal Investigator
Fred Hutchinson Cancer Research Center
United States: Federal Government
CDR0000710926
NCT01434329
October 2011
April 2013
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