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S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML


N/A
18 Years
N/A
Open (Enrolling)
Both
Leukemia

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Trial Information

S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML


OBJECTIVES:

- To identify differentially methylated regions (DMRs) associated with overall survival
(OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.

- To develop and evaluate in an independent validation set a prognostic score for OS
based on the identified DMR.

- To determine whether the prognostic score can group patients into risk groups based on
OS.

OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations
by CHARM array-based genome assay. Each patient's clinical data is also collected.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- De novo acute myeloid leukemia (AML) patients with normal cytogenetics treated with
curative therapy who survived at least 28 days after therapy started

- Samples will be taken from the following studies: SWOG-8600, SWOG-9031, SWOG-9333,
SWOG-9500, SWOG-S9918, SWOG-S0106, and SWOG-S0112

- Blood or marrow specimens can be used

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

Time Perspective: Retrospective

Outcome Measure:

Identification of DMRs associated with OS

Outcome Time Frame:

immediate

Safety Issue:

No

Principal Investigator

Min Fang, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

CDR0000710926

NCT ID:

NCT01434329

Start Date:

October 2011

Completion Date:

April 2013

Related Keywords:

  • Leukemia
  • untreated adult acute myeloid leukemia
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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