S8600-S9031-S9333-A, Identification of Differentially Methylated Genomic Regions That Are Prognostically Significant in AML
- To identify differentially methylated regions (DMRs) associated with overall survival
(OS) of acute myeloid leukemia (AML) patients with normal cytogenetics.
- To develop and evaluate in an independent validation set a prognostic score for OS
based on the identified DMR.
- To determine whether the prognostic score can group patients into risk groups based on
OUTLINE: Archived blood or bone marrow samples are analyzed for DNA methylation alterations
by CHARM array-based genome assay. Each patient's clinical data is also collected.
Time Perspective: Retrospective
Identification of DMRs associated with OS
Min Fang, MD, PhD
Fred Hutchinson Cancer Research Center
United States: Federal Government