The Effects of ß1-receptor Blockade and α1-adrenergic Agonist on the Kinetics of Lactated Ringer's Solution During Surgery
INTRODUCTION The renal clearance of infused crystalloid fluid is very low during anaesthesia
and surgery, but experiments in conscious sheep indicate that the renal fluid clearance
might approach a normal rate when the adrenergic balance is modified.
METHODS Sixty females (mean age, 32 years) undergoing laparoscopic gynecological surgery
were randomized to control group and received only the conventional anesthetic drugs and 20
ml/kg of lactated Ringer's over 30 min. The others were also given an infusion of 50
µg/kg/min of esmolol (beta1-receptor blocker) or 0.01 µg/kg/min of phenylephrine
(alpha1-adrenergic agonist) over 3 hours. The distribution and elimination of infused fluid
was studied by volume kinetic analysis based on urinary excretion and blood Hgb level.
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Supportive Care
Urine was collected via an indwelling catheter during 3 hours of surgery
Robert G Hahn, MD, PhD
Södertälje Hospital, Södertälje, Sweden; Section for Anesthesia, Linköping University, Linköping, Sweden
China: Food and Drug Administration