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The Effects of ß1-receptor Blockade and α1-adrenergic Agonist on the Kinetics of Lactated Ringer's Solution During Surgery


Phase 1/Phase 2
20 Years
50 Years
Not Enrolling
Female
Ovarian Cyst

Thank you

Trial Information

The Effects of ß1-receptor Blockade and α1-adrenergic Agonist on the Kinetics of Lactated Ringer's Solution During Surgery


INTRODUCTION The renal clearance of infused crystalloid fluid is very low during anaesthesia
and surgery, but experiments in conscious sheep indicate that the renal fluid clearance
might approach a normal rate when the adrenergic balance is modified.

METHODS Sixty females (mean age, 32 years) undergoing laparoscopic gynecological surgery
were randomized to control group and received only the conventional anesthetic drugs and 20
ml/kg of lactated Ringer's over 30 min. The others were also given an infusion of 50
µg/kg/min of esmolol (beta1-receptor blocker) or 0.01 µg/kg/min of phenylephrine
(alpha1-adrenergic agonist) over 3 hours. The distribution and elimination of infused fluid
was studied by volume kinetic analysis based on urinary excretion and blood Hgb level.


Inclusion Criteria:



- ASA group I

- Scheduled for laparoscopic removal of ovarian cyst or laparoscopic hysterectomy

Exclusion Criteria:

- ASA group > I

- Daily medication

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Supportive Care

Outcome Measure:

Urinary excretion

Outcome Description:

Urine was collected via an indwelling catheter during 3 hours of surgery

Outcome Time Frame:

3 hours

Safety Issue:

No

Principal Investigator

Robert G Hahn, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Södertälje Hospital, Södertälje, Sweden; Section for Anesthesia, Linköping University, Linköping, Sweden

Authority:

China: Food and Drug Administration

Study ID:

Esmolol study

NCT ID:

NCT01431612

Start Date:

November 2008

Completion Date:

October 2010

Related Keywords:

  • Ovarian Cyst
  • Pharmacokinetics, kidney;
  • Receptors, adrenergic;
  • Fluids, i.v.;
  • Sympathetic nervous system, esmolol;
  • Sympathetic nervous system, phenylephrine
  • Ovarian Cysts

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