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Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease: T2* Measurement in the Cortex and the Basal Ganglia


N/A
40 Years
80 Years
Open (Enrolling)
Both
Parkinson's Disease

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Trial Information

Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease: T2* Measurement in the Cortex and the Basal Ganglia


80 subjects (40 PD patients and 40 paired healthy volunteers (on sex and age)) aged 40-80
years will be included. PD patients will be recruited in the Department of Neurology of CHU
of Clermont-Ferrand. Healthy volunteers will be selected in clinical trial database. This
study will consist of one visit (at J0) during which subjects will undergo a MRI (a single
acquisition of 40 minutes approximately). PD patients will be further questioned on their
disease and will benefit from a neurological examination


Inclusion Criteria:



- For patients :

- Patients with idiopathic Parkinson's disease according to UKPDSBB criterias

- Men or women aged between 40 to 80 years

- not treated with deep brain stimulation

For healthy subjects

- Men or women aged between 40 to 80 years

Exclusion Criteria:

For patients

- Dementia (MMS<24)

- Contraindication to MRI.

- Under guardianship

- In excluding period for another study

For healthy subjects

- Antecedent of neurodegenerative diseases or psychiatric diseases

- Contraindication to MRI

- Under guardianship

- In excluding period for another study

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

The quantitative measurement of T2* in the cortex and basal ganglia using MRI, made à J0.

Outcome Time Frame:

at day 1

Safety Issue:

Yes

Principal Investigator

Miguel ULLA

Investigator Role:

Principal Investigator

Investigator Affiliation:

University Hospital, Clermont-Ferrand

Authority:

France: Ministry of Health

Study ID:

CHU-0097

NCT ID:

NCT01429909

Start Date:

February 2011

Completion Date:

February 2012

Related Keywords:

  • Parkinson's Disease
  • Functional magnetic resonance imaging
  • T2*
  • cortex and basal ganglia
  • Parkinson's disease
  • Synovial Cyst
  • Ganglion Cysts
  • Parkinson Disease

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