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A Prospective Study of Ablation of Pulmonary Focal Pure Ground Glass Opacity

Phase 3
20 Years
80 Years
Open (Enrolling)
Pulmonary Lesions

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Trial Information

A Prospective Study of Ablation of Pulmonary Focal Pure Ground Glass Opacity

Inclusion Criteria:

- The lesion(s) treated with ablation must be =< 2.0 cm in greatest dimension

- All patients are required to have been evaluated in a multi-disciplinary tumor
conference to ensure that the lesion is suitable for Image-guided percutaneous

- Platelet count ≥ 100 x 109/L

- International normalized ratio (INR) < 1.5

- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L

- A signed study specific consent form is required

Exclusion Criteria:

- Direct evidence of regional or distant metastases,or synchronous primary or prior
malignancy in the past 5 years

- Unable to lie flat or has respiratory distress at rest

- Uncontrolled coagulopathy or bleeding disorders

- Evidence of active systemic, pulmonary, or pericardial infection

- Women who are pregnant or breastfeeding

- Patients with poor pulmonary function

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

The changing of the lesion

Outcome Description:

To determine the efficacy rate of CT image guided ablation for pulmonary focal pGGO. To determine the feasibility and safety of CT image guided ablation in patients with pulmonary pGGO.

Outcome Time Frame:

3 years

Safety Issue:


Principal Investigator

Weisheng Chen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dongfang Hospital


China: Ministry of Health

Study ID:




Start Date:

September 2011

Completion Date:

December 2014

Related Keywords:

  • Pulmonary Lesions
  • pure pulmonary ground glass opacity