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Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery

18 Years
Not Enrolling
Colorectal Cancer

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Trial Information

Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery

Patients scheduled for open colorectal cancer surgery were randomly allocated to receive
general anesthesia (CON group, n=22) or general anesthesia with thoracic epidural anesthesia
(EPI group, n=21). Patients undergoing laparoscopic surgery (LAP group, n=20) composed the
third arm of the study. Measurement of perioperative changes in several hormones and
cytokines were blinded to group assignment.

Primary outcome: Compare simultaneously two types of surgical and anesthesia techniques for
colorectal cancer surgery and measure to what extent the stress response is lessened.

Inclusion Criteria:

- Patients scheduled for colorectal cancer surgery

Exclusion Criteria:

- Emergent surgery

- Intestinal obstruction

- Contraindication for epidural catheter placement

- Concomitant autoimmune disease

- Concomitant infectious disease

- Recent corticosteroids or anti-inflammatory medications

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Plasma levels of several cytokines after colorectal cancer surgery

Outcome Description:

We have measured and compared perioperative plasma levels of interleukin-1, interleukin-2, interleukin-6,monocyte chemotactic protein-1, interleukin-8, nitric oxide, C-reactive protein and procalcitonin in our three-group sample.

Outcome Time Frame:

within the first two days after surgery

Safety Issue:


Principal Investigator

Patricia Duque, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Gregorio Marañon Hospital


Spain: Comité Ético de Investigación Clínica

Study ID:

Complutense University 1



Start Date:

June 2007

Completion Date:

February 2010

Related Keywords:

  • Colorectal Cancer
  • Laparoscopy
  • Anesthesia, Epidural
  • Colorectal Neoplasms