Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery
Patients scheduled for open colorectal cancer surgery were randomly allocated to receive
general anesthesia (CON group, n=22) or general anesthesia with thoracic epidural anesthesia
(EPI group, n=21). Patients undergoing laparoscopic surgery (LAP group, n=20) composed the
third arm of the study. Measurement of perioperative changes in several hormones and
cytokines were blinded to group assignment.
Primary outcome: Compare simultaneously two types of surgical and anesthesia techniques for
colorectal cancer surgery and measure to what extent the stress response is lessened.
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
Plasma levels of several cytokines after colorectal cancer surgery
We have measured and compared perioperative plasma levels of interleukin-1, interleukin-2, interleukin-6,monocyte chemotactic protein-1, interleukin-8, nitric oxide, C-reactive protein and procalcitonin in our three-group sample.
within the first two days after surgery
Patricia Duque, MD
Gregorio Marañon Hospital
Spain: Comité Ético de Investigación Clínica
Complutense University 1