Inclusion Criteria:

- Age ≥ 18 years

- Histologically-confirmed diagnosis of non metastatic squamous-cell carcinoma of oral
cavity ; oropharynx, larynx or hypopharynx.

- Macroscopically complete resection of disease.

- High-risk histological features defined as :

Microscopically incomplete tumour resection and/or invasion of regional lymph nodes with
extracapsular extension (pN+R+)

- Indication of radio-chemotherapy

- Start of radio-chemotherapy within 8 weeks after surgery

- Performance Status (PS) ECOG <= 2

- Adequate Blood tests, renal and liver functions in the 15 days prior inclusion
defined as :

Hemoglobin > 9 g/dL Neutrophil count > 1500 x 109/L Platelets > 100 x 109/L Total
bilirubin < 1,5x upper limit of normal (ULN) SGOT and SGPT < 2,5 x ULN Alkaline
Phosphatase < 2,5 xULN Serum creatinine < 110 µmol/L or creatinine clearance > 55 ml/min
(estimated by Cockcroft Formula) Absence of proteinuria

- Women of childbearing age must use adequate means of contraception(oral hormon
contraceptive, intrauterine contraceptive device, double barrier method of
contraception).

- Mandatory affiliation with a healthy security insurance.

- Dated and signed written informed consent.

Exclusion Criteria:

- Macroscopic residual tumour after resection(R2)

- Metastatic disease

- Prior treatment for Head and neck cancer with chemotherapy, radiotherapy or any
cancer target therapy

- Prior or concomitant malignancies (except for basal cell skin cancer ; in situ
cervical carcinoma or other malignancies with a complete response > 5 years)

- History of heavy hypersensibility reaction to Cisplatin

- Uncontrolled pulmonary, cardiac , hepatic or renal disease.

- History of interstitial pneumopathy

- Significant cardiovascular disease :

Congestive cardiac failure> New York Heart Association (NYHA) Class II Myocardial
infraction within 6 months prior to inclusion Unstable angina Severe cardiac arrythmia
Uncontrolled hypertension while receiving appropriate medication (≥ 160 mm Hg systolic
and/or ≥ 90 mm Hg diastolic) Disorder of left ventricular function with ejection fraction
< 50% Severe cerebrovascular accident within 6 months prior to inclusion History of severe
thromboembolism within 6 months prior to inclusion Cardiovascular baseline QTcB >480 ms
(Calculated with Bazett Formula) Bradycardia Electrolytic disorders

- Hepatic affection like : hepatitis B or C chronic advanced decompensated hepatitis
hepatitic cirrhosis or newly treated chronic hepatitis or nowadays treated with
immunosuppressive drugs severe auto-immune hepatitis or disease

- HIV known history

- Recent digestive symptoms with diarrhea as :

Crohn's disease malabsorption syndrome diarrhea Grade CTC ≥ 2

- Active drug or alcohol use or dependence

- Pregnant or breast-feeding women , or no use of effective birth control methods for
women of childbearing potential, , or men who don't accept to use an effective birth
control methods during the study

- Impossible follow-up