Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)
N/A
N/A
N/A
N/A
N/A
Not Enrolling
Both
Sarcoma
Both
Sarcoma
Trial Information
Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)
OBJECTIVES:
- To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS)
tumor samples.
OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1,
Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies.
Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS)
tumor stage, and RMS tumor subtype.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Tumor tissue samples from children with rhabdomyosarcoma (RMS) enrolled in the
Children's Oncology Group clinical trials
- Alveolar rhabdomyosarcoma (ARMS)
- Embryonal rhabdomyosarcoma (ERMS)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
RMS protein expression profile
Safety Issue:
No
Principal Investigator
Corinne M. Linardic, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Duke Cancer Institute
Authority:
Unspecified
Study ID:
CDR0000710565
NCT ID:
NCT01426945
Start Date:
November 2011
Completion Date:
Related Keywords:
- Sarcoma
- alveolar childhood rhabdomyosarcoma
- previously treated childhood rhabdomyosarcoma
- previously untreated childhood rhabdomyosarcoma
- recurrent childhood rhabdomyosarcoma
- embryonal childhood rhabdomyosarcoma
- Rhabdomyosarcoma
- Sarcoma
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