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Diet Composition and Genetics: Effects on Weight, Inflammation and Biomarkers

21 Years
Open (Enrolling)
Obese, Nondiabetic

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Trial Information

Diet Composition and Genetics: Effects on Weight, Inflammation and Biomarkers

Inclusion Criteria:

- Aged 21 years and older

- Have BMI >30.0 kg/m2 and <40 kg/m2

- Willing and able to participate in clinic visits, group sessions, and telephone and
Internet communications at specified intervals

- Able to provide data through questionnaires and by telephone

- Willing to maintain contact with the investigators for 12 months

- Willing to allow blood collections

- No known allergy to tree nuts

- Able to be physically active

Exclusion Criteria:

- Diabetic

- Inability to be moderately physically active

- A history or presence of a comorbid diseases for which diet modification and
increased physical activity may be contraindicated

- Currently pregnant/breastfeeding

- Planning to become pregnant within the next year

- Currently enrolled in a weight loss program or diet intervention study

- Current use of weight loss medication or supplements

- Planned surgical procedure that can impact the conduct of the study

- Have plans to relocate from area within the next year

- 6+ months use of meds likely to cause weight gain or prevent weight loss

- Any condition which in the opinion of the investigator makes the subject unsuitable
for inclusion in this study

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

Weight loss

Outcome Description:

Weight loss response, depending on insulin status, to diets that differ in macronutrient composition: 1) higher carbohydrate and lower fat, 2) lower carbohydrate and higher monounsaturated fat [MUFA] or 3) lower carbohydrate and walnut-rich higher fat

Outcome Time Frame:

1 year

Safety Issue:


Principal Investigator

Cheryl Rock, PhD, RD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of California, San Diego


United States: Institutional Review Board

Study ID:




Start Date:

December 2011

Completion Date:

June 2016

Related Keywords:

  • Obese
  • Nondiabetic
  • Obese
  • Women
  • Weight loss
  • Exercise
  • Physical activity
  • Diet
  • Female



Moores UCSD Cancer Center La Jolla, California  92093-0658