Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
Patients with high risk or relapsed acute lymphoblastic leukaemia (ALL) have a worse
prognosis compared to all other patients with ALL. For these patients additional therapy
approaches are required after they have achieved remission with multimodal chemotherapy.
Allogeneic haematopoetic stem cell transplantation shows promising results mainly due to an
immunological antileukaemic control by the graft-versus-leukaemia effect, but treatment
related mortality and morbidity remains a serious problem.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Event-free and overall survival after allogeneic HSCT
Arend v. Stackelberg, MD, PhD
ALL-REZ BFM Study Center Berlin Germany
Austria: Federal Ministry for Health Family and Youth
ALL-SZT- BFM 2003