Assessment of Four-dimensional (4D) 18F-fluoro-deoxy-glucose (FDG) Positron Emission Tomography and Computed Tomography System (PET-CT) in Radiotherapy for Non Small Cell Lung Cancers (NSCLC)
Many PET studies have been interested in lung radiotherapy volumes definition, however
lacking any standardisation. Effectively, the use of PET images is difficult because of the
poor image quality resulting from noise and partial volume effects induced blurring.
Moreover, due to the long duration of PET acquisitions, respiratory motions are inevitable
and result in artifacts in the PET images affecting the volumes and contrast of the tumour:
tumours may appear larger while their activity can be lower. To overcome these limitations,
we propose to use a 4D PET-CT, ie a PET-CT acquisition system synchronized with respiration
in order to compare CT-simulation target volumes and PET target volumes after application of
different approaches for partial volume effect correction, respiratory motion correction and
automatic segmentation method of functional volumes. For this purpose, patients with a non
small cell lung cancer and having to be treated with radiotherapy or radio-chemotherapy
underwent CT-simulation and 4D PET-CT in radiotherapy treatment position. The target volumes
and the dosimetries obtained with both modalities were compared.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Quantitative and qualitative differences between CT-simulation and 4D PET-CT volumes
Quantitative and qualitative differences between the radiotherapy target volumes obtained from CT-simulation and from 4D-PET-CT. The quantitative difference is expressed as a percentage of the total volume defined on CT simulation. The qualitative difference is defined as the volumes defined only on CT-simulation or only on 4D-PET-CT, expressed as a percentage of the total volume defined on CT-simulation.
between day 7 and day 21 after inclusion
Philippe FERNANDEZ, Pr
University Hospital, Bordeaux, France
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)