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Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

18 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be
acquired. MR acquisition will be performed without extrinsically administered contrast,
using a balanced turbo field echo (TFE) sequence and commercially available coils.

Inclusion Criteria:

- AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using
radiotherapy will be eligible for this study.

- Any types and amounts of prior therapy will be allowed for this study.

- Subjects must be greater than or equal to 18 years of age. There are no gender or
ethnic restrictions.

- Ability to understand and the willingness to sign a written informed consent

- Able to tolerate supine position

- ECOG performance status of 3 or less

Exclusion Criteria:

- MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical
devices e.g., cardiac pacemakers

- Women who are pregnant or trying to get pregnant

- Pain in supine position

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Outcome Measure:

To measure time series of MRI imaging by the b-SSFP sequence.

Outcome Description:

To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.

Outcome Time Frame:

6 weeks

Safety Issue:


Principal Investigator

Amit Sawant, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

UT Southwestern Medical Center


United States: Institutional Review Board

Study ID:

STU 042011-034



Start Date:

September 2011

Completion Date:

December 2014

Related Keywords:

  • Lung Cancer
  • Lung Neoplasms



Ut Southwestern Medical CenterDallas, Texas  75390