Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography of Indocyanine Green
In our study the investigators prospectively include patients with colon cancer requiring
elective surgical operation. All types of colon resection were carried out according to
standard procedures. Guidelines for preoperative examination according to NGICG (Norwegian
Gastro-Intestinal Cancer Group) to grade the disease, select the most suitable patients and
plan further treatment.
Microcirculation of colon wall was assessed by dynamic
laser-induced-fluorescence-videoangiography (IC-VIEW, PULSION Medical Systems AG, Munich,
Germany) of indocyanine green (ICG). ICG is a water-soluble tricarbocyanine dye that binds
strongly to plasma proteins after intravenous injection and is exclusively distributed in
intravascular space. Additionally this system houses a laser (energy Pi = 0.16 W, wavelength
= 780 nm) that causes excitation/illumination of the fluorescence light from intravascular
plasma bound ICG. This light has a spectral range near-infrared energy (NIR) with a maximum
at 805 nm and emits fluorescence at 835 nm. It passes through infrared filter on a digital
video camera and results in recording of real time fluorescent image from perfusion of
plasma bound ICG within small plexus of blood vessels in the bowel wall. Besides that it
also demonstrates perfusion from surrounding structures such as appendix epiploic and
pericolic fat. The maximum penetration of the laser into tissue is 3-5 mm and general normal
thickness of colon wall is 3-5 mm. This method makes it a presentable tracer for tissue
perfusion of anterior bowel wall.
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
Evaluation of microcirculation in colon wall and bowel anastomosis by laser induced fluorescence video angiography of indocyanine green
The purpose of our study is to evaluate the microcirculation in the colon wall and bowel anastomosis with laser-induced-fluorescence videoangiography of indocyanine green (ICG), before and after bowel resection.
2 min
Yes
Muiz A. Chaudhry, MD
Principal Investigator
Ostfold Hospital Trust HF
Norway:National Committee for Medical and Health Research Ethics
Microcirculation of colon
NCT01419860
January 2010
December 2016
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