DNA Methylation-based Assays for Detecting Disease Spread in Rhabdomyosarcoma
N/A
18 Years
Both
Sarcoma
Trial Information
DNA Methylation-based Assays for Detecting Disease Spread in Rhabdomyosarcoma
OBJECTIVES:
- To establish a panel of hypermethylation assays for minimal disseminated disease
analysis in rhabdomyosarcoma (RMS).
- To apply the hypermethylation assays to a series of bone marrow specimens from RMS
patients.
OUTLINE: Archived tumor, bone marrow, and peripheral blood samples are analyzed for DNA
hypermethylation by PCR-based assays and microarray assays. Results are then compared with
each patient's clinical and pathological characteristics, and outcomes. Patterns of locus
hypermethylation in tumor and paired bone marrow samples are also compared.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosed with rhabdomyosarcoma (RMS)
- Tumor, bone marrow, and peripheral blood samples from the Children's Oncology Group
D9803 trial of intermediate-risk RMS
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Panel of hypermethylation assays for minimal disseminated RMS
Safety Issue:
No
Principal Investigator
Stephen R. Master, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Pennsylvania
Authority:
United States: Federal Government
Study ID:
CDR0000709088
NCT ID:
NCT01419509
Start Date:
August 2011
Completion Date:
Related Keywords:
- Sarcoma
- alveolar childhood rhabdomyosarcoma
- embryonal childhood rhabdomyosarcoma
- embryonal-botryoid childhood rhabdomyosarcoma
- mixed childhood rhabdomyosarcoma
- pleomorphic childhood rhabdomyosarcoma
- previously untreated childhood rhabdomyosarcoma
- nonmetastatic childhood soft tissue sarcoma
- Rhabdomyosarcoma
- Sarcoma
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