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Status and the Application of Topotecan at Post-operation Treatment of Cervical Cancer


N/A
20 Years
70 Years
Open (Enrolling)
Female
Cervical Cancer

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Trial Information

Status and the Application of Topotecan at Post-operation Treatment of Cervical Cancer


Cervical cancer has a very high morbidity. Many patients need additional therapy after
surgery in order to elevate the survival rate and life quality. In this research, we are
going to give additional therapy to patients who have big tumor, deep invasion or tumor
thrombi in the vascular system after surgery. randomized control method will be used in this
research, in order to compare the survival rate and side effects between radiation therapy
only, concurrent chemoradiotherapy, and concurrent chemoradiotherapy with additional
chemotherapy. 3D-CRT and Topotecan will be used in this research.


Inclusion Criteria:



1. patients who underwent the cervical cancer radical surgery in three months have higt
risk factors which including deep stromal invasion,large primary tumour and/or
lymphovascular spase invasion;

2. squamous carcinoma;

3. ageļ¼œ70;

4. Gynecologic Oncology Group (GOG):0-2.

Exclusion Criteria:

1. negative nodes,surgical margin,and/or parametrium;

2. No serious damage to the liver and kidney function, no hypertension,diabetes and
other effects of therapy complications.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Chen M W, M.D

Investigator Role:

Study Director

Investigator Affiliation:

Affiliated Hospital of Medical College of Xo'an Jiaotong University

Authority:

China: Ministry of Health

Study ID:

GCR-01

NCT ID:

NCT01418859

Start Date:

August 2011

Completion Date:

December 2015

Related Keywords:

  • Cervical Cancer
  • cervical cancer
  • postoperation
  • chemotherapy
  • radiotherapy
  • Uterine Cervical Neoplasms

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