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Determination of the Absolute Bioavailability of GSK1120212 Following a Single Oral Dose Co-Administered With an Intravenous Radiolabelled Microdose of GSK1120212 in Subjects With Solid Tumors

Phase 1
18 Years
Not Enrolling

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Trial Information

Determination of the Absolute Bioavailability of GSK1120212 Following a Single Oral Dose Co-Administered With an Intravenous Radiolabelled Microdose of GSK1120212 in Subjects With Solid Tumors

This Phase I, open-label, non-randomized study is designed to determine the absolute
bioavailability of the standard 2 mg tablet formulation of GSK1120212 co-administered with
an intravenous microdose (5 μg) dose of [14C]-labelled GSK1120212 (7.4 kBq) in subjects with
solid tumors. Pharmacokinetic sampleswill be obtained up to 10 days post-dose. Safety
assessments, including assessment of adverse events, clinical laboratory values (hematology
and clinical chemistry) and vital signs, will be performed throughout the study. After
completing all assessments, eligible subjects may transition to MEK114375, an open-label,
rollover study to continue treatment with GSK1120212.

Inclusion Criteria:

1. Male or female at least 18 years of age at the time of signing the informed consent

2. Histologically or cytologically confirmed diagnosis of a solid tumor that is not
responsive to standard therapies or for which there is no approved therapy.

3. Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form

4. Body weight greater than or equal to 45 kg and a body mass index greater than or
equal to 19 kg/m2 and less than 35 kg/m2 (inclusive)

5. Able to swallow and retain oral medication

6. Has an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

7. Women of child-bearing potential and men with reproductive potential must be willing
to practice acceptable methods of birth control (see Section 7.1). Additionally,
women of childbearing potential must have a negative serum pregnancy test within 14
days prior to the first dose of study treatment;

8. Men with a female partner of childbearing potential must have either had a prior
vasectomy or agree to use effective contraception as described in Section 7.1 from
the time of first dose of study treatment until 16 weeks following the last dose of
study treatment (based on the lifecycle of sperm).

9. Must have adequate organ function as defined in Table 4:

Table 4 Definitions for Adequate Baseline Organ Function System
Laboratory Values Hematologic Absolute neutrophil count greater than or equal to 1.2 ×
109/L Hemoglobin greater than or equal to 9 g/dL Platelets
greater than or equal to 75 × 109/L Prothrombin time (PT), International
normalization ratio (INR)a and Partial thromboplastin time (PTT) less than or equal to 1.5
times ULN Total bilirubin less than or equal to 1.5 times ULN ALT
less than or equal to 2.5 times ULN Creatinine or
less than or equal to 1.5 times ULN Calculated creatinine clearance b or greater than or
equal to 50 mL/min 24-hour urine creatinine clearance greater than or equal to 50 mL/min
LVEF greater than or equal to LLNc by ECHO or MUGA

1. INR greater1.5 times ULN will be acceptable in case of subjects receiving therapeutic
anticoagulants such as warfarin as long as INR is monitored during the study
according to clinical practice.

2. Calculated by the Cockcroft-Gault formula (see Appendix 4).

3. If LLN is not defined for a given institution, then ejection fraction must be greater
than or equal to 50%. NOTE: Subjects with ALT or bilirubin values outside the
range(s) in the table due to Gilbert's syndrome or asymptomatic gallstones are not
excluded. Laboratory results obtained during Screening should be used to determine
eligibility criteria. In situations where laboratory results are outside the
permitted range, the investigator may opt to retest the subject and the subsequent
within-range screening result may be used to confirm eligibility.

Exclusion Criteria:

1. Currently receiving cancer therapy (e.g., chemotherapy with delayed toxicity,
extensive radiation therapy, immunotherapy, biologic therapy, or major surgery)
within the last 3 weeks; chemotherapy regimens without delayed toxicity within the
last 2 weeks; or use of an investigational anti-cancer drug within 28 days preceding
dosing of GSK1120212; use of any other investigational product within 30 days, 5
half-lives or twice the duration of the biological effect of the investigational
product (IP) (whichever is longest);

2. Has participated in a 14C human research study in the 12 months prior to
administration of study treatment;

3. Current use of a prohibited medication (Section 8.2) or requires any of these
medications during the study NOTE: Use of anticoagulants such as warfarin is
permitted; however, INR must be monitored in accordance with local institutional

4. Has unresolved Grade 2 or greater toxicity (based on NCI-CTCAE, version 4.0) [NCI,
2009] from previous anti-cancer therapy except alopecia and Grade 2 anemia level.

5. Has pre-existing Grade 2 or greater peripheral neuropathy.

6. Has participated in a study that resulted in or made a donation of blood or blood
products in excess of 500 mL within 56 days of the first dose of study treatment.

7. Has presence of active GI disease or other condition (e.g., gastrectomy, bariatric
surgery, small or large bowel resection, or cholecystectomy should be excluded) that
may interfere significantly with the absorption of drugs. If clarification is needed
as to whether a condition will significantly affect absorption of drugs, contact the
GSK Medical Monitor.

8. Has any serious and/or unstable pre-existing medical (aside from malignancy exception
above), psychiatric disorder, or other conditions that could interfere with subject's
safety, obtaining informed consent or compliance to the study procedures, in the
opinion of the investigator or GSK Medical Monitor.

9. Has a history of interstitial lung disease or pneumonitis.

10. Has a history or current evidence/risk of RVO or CSR:

- History of RVO or CSR, or predisposing factors to RVO or CSR (i.e., uncontrolled
glaucoma or ocular hypertension, uncontrolled systemic disease such as
hypertension or diabetes mellitus, or history of hyperviscosity or
hypercoagulability syndromes)

- Visible retinal pathology as assessed by ophthalmic exam that is considered a
risk factor for

RVO or CSR such as:

- Evidence of new optic disc cupping

- Intraocular pressure >21 mmHg as measured by tonography

11. Has symptomatic or untreated leptomeningeal or brain metastases or spinal cord

Note: Subjects previously treated for these conditions that have had stable central
nervous system disease (verified with consecutive imaging studies) for >3 months, are
asymptomatic and are not currently taking corticosteroids, or are on stable dose of
corticosteroids for at least 1 month prior to Day 1 of the study are permitted.

12. QTcF (preferred) or QTcB greater than or equal to 480 msec.

13. Has a history or evidence of cardiovascular risk including any of the following:

- History or evidence of current clinically significant uncontrolled arrhythmias.

Subjects with controlled atrial fibrillation for >30 days prior to enrollment are

- History of acute coronary syndromes (including myocardial infarction and unstable
angina), coronary angioplasty, or stenting within 6 months prior to enrollment.

- History or evidence of current ≥ Class II congestive heart failure as defined by New
York Heart Association [NYHA, 1994] (Appendix 3) NOTE: Subjects with BBB are not
excluded from this study; however, if the underlying cause of the BBB is exclusionary
or if the BBB is new onset (therefore, potentially reflective of an evolving cardiac
condition), the subject should be excluded.

Type of Study:


Study Design:

Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Determine the the absolute bioavailability of GSK1120212 following single oral tablet dose co-administered with an IV microdose.

Outcome Description:

Absolute bioavailability (F) of GSK1120212 calculated as the ratio of dose-normalized area under the concentration-time curve from time 0 (pre-dose) extrapolated to infinity (AUC(0-inf)) of oral to IV dosing

Outcome Time Frame:

Pre-dose, 0.5h, 1h, 1.5h, 1.55h, 1.75h,2h, 2.5h, 3h, 4h, 5h, 6h, 8h, 10h, 24h, 48h, 72h, 120h, 168h, and 240h.

Safety Issue:


Principal Investigator

GSK Clinical Trials

Investigator Role:

Study Director

Investigator Affiliation:



United States: Food and Drug Administration

Study ID:




Start Date:

June 2011

Completion Date:

December 2011

Related Keywords:

  • Cancer



GSK Investigational Site Seattle, Washington  98133