Perfusion Computed Tomography Pilot Study in the NCRN FOXFIRE Clinical Trial to Determine Blood Flow to Liver Metastases
Phase 0
18 Years
N/A
18 Years
N/A
Open (Enrolling)
Both
Metastatic Colorectal Cancer
Both
Metastatic Colorectal Cancer
Trial Information
Perfusion Computed Tomography Pilot Study in the NCRN FOXFIRE Clinical Trial to Determine Blood Flow to Liver Metastases
Inclusion Criteria:
- Patients who have given written informed consent to participate in the FOXFIRE
clinical trial and have not yet started chemotherapy treatment in the trial.
- Serum creatinine and calculated glomerular filtration rate are less than the upper
limit of normal (ULN) in blood tests performed up to 29 days before entry into the
FOXFIRE clinical trial.
- Liver metastasis 1.0 to4.0 cm in cranio-caudal diameter on imaging performed up to 29
days before entry into the FOXFIRE clinical trial
Exclusion Criteria:
- True allergy to intravenous iodinated CT contrast
- Active medical or psychological illness that would render the patient unsuitable for
the additional imaging proposed in this pilot study, at the discretion of the
investigator
Type of Study:
Interventional
Study Design:
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Outcome Measure:
Recruitment rate to this voluntary study and acquisition of sufficient data for perfusion analysis
Outcome Time Frame:
2 years
Safety Issue:
No
Principal Investigator
Ricky A Sharma, MB BChir
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Oxford
Authority:
UK: National Research Ethics Service
Study ID:
10/H0505/95
NCT ID:
NCT01410760
Start Date:
April 2011
Completion Date:
Related Keywords:
- Metastatic Colorectal Cancer
- Imaging study
- Perfusion Computerised Tomography
- Colorectal Neoplasms
- Neoplasm Metastasis
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