The Influence of KIR and HLA Genotype on the Response to Rituximab Immunotherapy in Patients With Follicular Lymphoma
18 Years
N/A
Both
Lymphoma
Trial Information
The Influence of KIR and HLA Genotype on the Response to Rituximab Immunotherapy in Patients With Follicular Lymphoma
OBJECTIVES:
- To test the influence of killer immunoglobulin-like receptor (KIR) and human lymphocyte
antigen (HLA) genotype on response to anti-CD20 antibody lymphoma immunotherapy.
OUTLINE: DNA samples are analyzed for killer immunoglobulin-like receptor (KIR) and human
lymphocyte antigen (HLA) genotyping with sequence-specific primers (SSP) by real-time PCR.
KIR and HLA typing are analyzed according to KIR-HLA matched vs mismatched, KIR B haplotype
content, and the number of inhibitory KIR-HLA pairs. Results are then correlated to each
patient's overall response and duration of response to rituximab.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients diagnosed with follicular lymphoma enrolled on ECOG-E4402
- Treated with single-agent rituximab; the trial compared two different
rituximab-dosing strategies - maintenance vs retreatment as needed
- Available germline DNA samples isolated from peripheral blood as well as clinical
evaluation of disease status prior to and at initial response to the therapy
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
KIR-HLA genotype predictive of antibody-dependent cell-mediated cytotoxicity (ADCC)-based cancer immunotherapy
Safety Issue:
No
Principal Investigator
Erik Ranheim, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Wisconsin, Madison
Authority:
Unspecified
Study ID:
CDR0000706811
NCT ID:
NCT01406782
Start Date:
August 2011
Completion Date:
Related Keywords:
- Lymphoma
- stage III grade 1 follicular lymphoma
- stage III grade 2 follicular lymphoma
- stage IV grade 1 follicular lymphoma
- stage IV grade 2 follicular lymphoma
- Lymphoma
- Lymphoma, Follicular
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