Inclusion Criteria:

- Patients with histopathologically or clinically confirmed diagnosis of hepatocellular
carcinoma

- Patients with Child-Pugh classification A or B

- Patients unresponsive to standard therapy or for whom standard therapy is
intolerable, or for whom there is no appropriate therapy

- Patients who are able to take oral medication

- Patients age 20 to 79 years (inclusive) at time of informed consent

- Patients with an ECOG performance status score of 0-2

- Patients have the eligible organ function.

Exclusion Criteria:

- Patients with a primary malignant tumor

- Patients with a history of liver transplant

- Patients with brain metastases

- Patients with a complication of uncontrolled

- Patients with a psychiatric disorder that might cause difficulty in obtaining
informed consent or in conducting the trial