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Exploration of New Biologic Factors' Predictive Value , Especially Circulating VE-cadherin in Metastatic Colorectal Adenocarcinoma Patients Treated With Bevacizumab


N/A
18 Years
N/A
Open (Enrolling)
Both
Colorectal Cancer, Metastasis

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Trial Information

Exploration of New Biologic Factors' Predictive Value , Especially Circulating VE-cadherin in Metastatic Colorectal Adenocarcinoma Patients Treated With Bevacizumab


Inclusion Criteria:



- Patient with a metastatic colorectal cancer proved histologically and treated with
bevacizumab in first line.

- At least one extra-osseous, non-irradiated, measurable site (>= 10 mm with spiral
CT).

- No prior radiotherapy treatment unless treatment is over for at least 4 weeks.

- Adult patients.

- PS <= 2.

- Life expectancy greater than 3 months.

- Mandatory affiliation with a healthy security insurance.

- Signed written informed consent.

Exclusion Criteria:

- Prior chemotherapy for the metastatic cancer.

- Prior bevacizumab treatment.

- Other current cancer or previous cancer detected in the last 5 years that can be
linked to the current disease.

- Patient deprived of freedom.

- Pregnant or lactating women.

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label

Outcome Measure:

Response rate to treatment

Outcome Description:

A 30% response rate (complete or partial response) to treatment is expected. The response will be assessed according to RECIST criteria. This primary outcome measure is defined by the observation of at least one objective response during the treatment. This outcome measure will be correlated to biological factors.

Outcome Time Frame:

Up to 1 year at most

Safety Issue:

No

Principal Investigator

Christelle DE LA FOUCHARDIERE, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Centre Léon Bérard

Authority:

France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Study ID:

AVECC

NCT ID:

NCT01405430

Start Date:

May 2010

Completion Date:

November 2014

Related Keywords:

  • Colorectal Cancer
  • Metastasis
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Colorectal Neoplasms
  • Neoplasm Metastasis

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