Inclusion Criteria

The key inclusion criteria are listed below:

- Histological diagnosis of primary HCC

- Curative resection within 4-6 weeks prior to randomisation (proven by clear resection
margin (> 0.1 cm) + negative chest and tri-phasic contrast enhanced spiral CT scan +
negative abdominal contrast enhanced MRI). Patients with residual lymph node
metastases should not be enrolled.

- Known positive serum HBsAg or known HCV in serum

- ECOG PS 0-1

- Child Pugh score < 8

The key exclusion criteria are listed below:

- Pathological confirmation of single tumour <2cm in diameter from most recent
hepatectomy

- History of immune-mediated thrombocytopenia, other platelet disorders, laboratory
evidence of anti-heparin antibodies, or prior history thereof

- Metastatic tumour or co-existing malignant disease

- Prior history of malignancy except non-melanomatous skin cancer or treated in-situ
carcinoma of the cervix

- Prior recurrence of HCC or any liver resection prior to the most recent resection

- Prior HCC therapy including chemotherapy, radiotherapy, molecular targeted agents,
vaccines, liver transplantation or surgical resection prior to most recent
hepatectomy. Pre-operative portal vein embolisation is permitted

- Planned liver transplantation

- History of allergic and/or hypersensitivity and/or significant adverse reactions to
heparin or other anticoagulants

- Concomitant aspirin (>150mg/day), vitamin K antagonists (other than low dose
prophylaxis), NSAIDs (except COX-2 inhibitors), heparin within 2 weeks prior to
randomisation or other anti-platelet drugs.

- History of allergic, anaphylactic or significant adverse reaction to radiographic
contrast media which cannot be managed by pre-treatment prophylaxis or patient
unsuitable for CT or MRI scanning.

- Known seropositivity to HIV

- Inflammatory bowel disease , abnormal bleeding tendency or at risk of bleeding due to
open wounds or planned surgery

- Acute substance abuse including alcohol

- Anticancer therapy or investigational agent in the previous 4 weeks