Inclusion Criteria:

- Diffuse large B-cell lymphoma (DLBCL) with activating mutations in CD79 (A or B
subunits). DLBCL that arose from transformed indolent lymphoma is allowed.

- Prior treatment and relapse following anthracycline-based chemotherapy and autologous
bone marrow or stem cell transplant. Patients who are not transplant eligible may be
considered for the study following a single regimen of chemotherapy such as R-CHOP or
R-EPOCH alone. There is no limit to prior therapy allowed.

- Patients may be treated with localized radiation to as many as two sites of
disease, so long as measurable or evaluable disease remains at untreated sites.

- Patients may be treated with corticosteriods immediately prior to enrollment and
during the course of the study treatment as long as steriod treatment is tapered
to a toal daily dosage of 10mg or less of prednisone (or it's equivalent) prior
to AEB071 administration

- WHO performance status of ≤2

Exclusion Criteria:

- Patients at screening who are treated with strong inducers or inhibitors of
cytochrome P450 3A4 (CYP3A4) that can not be discontinued.

- Impaired cardiac function or clinically significant cardiac diseases, including any
of the following:

- History or presence of ventricular tachyarrhythmia

- Presence of unstable atrial fibrillation (ventricular response > 100 bpm); Patients
with stable atrial fibrillation are eligible, provided they do not meet any of the
other cardiac exclusion criteria.

- Angina pectoris or acute myocardial infarction ≤ 3 months prior to starting study
drug

- Other clinically significant heart disease (e.g., symptomatic congestive heart
failure; uncontrolled arrhythmia or hypertension; history of labile hypertension or
poor compliance with an antihypertensive regimen)

- Patients with another malignancy that was treated within the last three years with
the exceptions of localized basal cell carcinoma and cervical carcinoma.

- Patients with impairment of GI function or GI disease that could interfere with the
absorption of AEB071.

- Patients with a known history of Human Immunodeficiency Virus (HIV)

- HIV testing is not required as part of this study

- Patients with a known history of active hepatitis B or C infection unless they are on
antiviral therapy

- The determination of active hepatitis status should be as per standard of care
at each site

- Hepatitis B and C testing is not required as part of this study

Time since the last prior therapy for treatment of underlying malignancy**:

- Cytotoxic chemotherapy: ≤ than the duration of the most recent cycle of the previous
regimen (with a minimum of 2 weeks for all)

- Biologic therapy (e.g., antibodies): ≤ 4 weeks

- ≤ 5 x t1/2 of a small molecule therapeutic, not otherwise defined above

**Patients must have recovered or stabilized from all toxicities related to their
previous treatment except for alopecia

- Patients with any history of significant coagulopathy or a medical condition
requiring long term systemic anticoagulation that would interfere with biopsies.

- Patients having undergone major surgery less than 4 weeks prior to enrollment or that
have not fully recovered from prior surgery.

- Pregnant or nursing (lactating) women

Other protocol-defined inclusion/exclusion criteria may apply