Trial Information

Perioperative fluid administration is a common therapy in clinical practice, and recent
regime has a history about 50 years. Recently, clinicians found that traditional regime had
some disadvantages, for example, pulmonary edema, increased cardiac load, increased body
weight. And thus, perioperative fluid restriction regimen has been suggested and proved
could reduce cardiopulmonary complications and mortality rates after major elective
gastrointestinal surgery.

Patients were divided into two groups randomly and underwent restricted fluid regimen or
traditional fluid regimen. We determined the complications and immunological function in two
groups, and analyzed the relationship between complications and immunological changes. Based
on this we decide the probable mechanism that perioperative fluid restriction effects on
complications.