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Developing Individualized Strategies to Prevent Nausea and Vomiting

21 Years
70 Years
Not Enrolling
Postoperative Nausea and Vomiting, Genetic Polymorphisms

Thank you

Trial Information

Developing Individualized Strategies to Prevent Nausea and Vomiting

Inclusion Criteria:

- adult (i.e. at least 21 years of age) ambulatory surgery patients, with a duration of
1-4 hours

- able to understand, read, and write in English, are ASA physical status 1-3, and are
high risk PDNV patients (with 3 or more of the following risk factors:

- female gender

- age < 50

- history of PONV and/or currently prone to motion sickness, and expectation of post-op
opioid use).

Exclusion Criteria:

- patients not at high risk for PDNV (as described above)

- patients <21 years of age

- planned inpatient surgical patients

- planned total intravenous anesthesia, sedation, or regional technique without inhaled

- inability to provide informed consent in English

- pregnant or breastfeeding

- persistent and/or current nausea/vomiting.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Outcome Measure:

Incidence of post-discharge nausea and vomiting (PDNV)

Outcome Time Frame:

48 hours post-discharge

Safety Issue:



United States: Institutional Review Board

Study ID:




Start Date:

April 2012

Completion Date:

November 2015

Related Keywords:

  • Postoperative Nausea and Vomiting
  • Genetic Polymorphisms
  • Nausea
  • Vomiting
  • Postoperative Nausea and Vomiting



University of Kansas Medical Center Kansas City, Kansas  66160-7353
University of California, San Francisco San Francisco, California  94143
Cleveland Clinic Cleveland, Ohio  44195
Ohio State University Medical Center Columbus, Ohio  43210
Brigham & Women's Hospital Boston, Massachusetts  02115
University of Kentucky Hospital Lexington, Kentucky  40536