Inclusion Criteria:

- Informed consent form

- Age 65-85，both genders

- HNSCC Confirmed by pathology

- Primary site of oral cavity, oropharynx, hypopharynx, larynx

- Stage Ⅲ/ⅣA,B

- Primary lesions can be measured

- Karnofsky's Performance Scale ≥60

- Life expectancy of more than 6 months

- Haemoglobin≥100g/L ,WBC ≥3.5×109/L, platelet count≥90×109/L

- Hepatic function: ALT、AST< 1.5 x ULN, TBIL< 1.5 x ULN

- Renal function: Creatinine < 1.5 x ULN

Exclusion Criteria:

- Received other anti EGFR monoclonal antibody treatment

- Previous chemotherapy or radiotherapy

- Participation in other interventional clinical trials within 1 month

- Other malignant tumor (except of non-melanoma skin Cancer or carcinoma in situ of
cervix)

- History of serious allergic or allergy

- History of Serious lung or heart disease