Inclusion Criteria:

1. Hepatocellular Carinomas with diagnosis of pathology or cytology or consistent with
China 2001 guideline of Clinical Diagnosis Hepatocellular Carinomas

2. clinical stage（The Barcelona Liver Clinic staging system,BCLC B and C)，or can not
receive surgical intervention

3. liver function:Child-Pugh A、B

4. PST 0—1（Eastern Cooperative Oncology Group Performance Score ,ECOG）

5. Lifespan≥6 months

6. First time to receive treatment

7. Can accept the follow up

8. informed consent was gotten

9. the number of lesion ≤ 5

Exclusion Criteria:

1. pregnant or lactation woman

2. emotional disturbance

3. serious heart ,lung disfunction or serious diabetes mellitus

4. serious reactiveness infections;（exp:type B or C hepatitis）

5. liver function :Child-Pugh Score C

6. thrombocyte＜6×109/L

7. diffuse HCC

8. widespread metastasis

9. serious atherosclerosis

10. acquired immunodeficiency syndrome;AIDS

11. thrombosis or thrombosis event in 6 months

12. renal inadequacy who need hemodialysis or peritoneal dialysis

13. with other tumors except basal cell carcinoma and carcinoma in situ of cervix

14. serious alimentary tract hemorrhage in 4 weeks