MR-PET Guided Biologically Optimised Interstitial Brachytherapy for Postoperative Recurrent Cervical Cancers
Aim 1: To spatially characterize biologically heterogenous subvolumes within the gross tumor
through multimodality (18 F-Miso/FLT/Functional MR) image fusion.
Aim 2: To evaluate post external beam radiotherapy (EBRT) response in spatial reference to
biological heterogeneous sub-volumes on imaging.
Aim 3: To evaluate technical feasibility of delivering dose modulated biologically optimized
Aim 4: To evaluate acute and late toxicity and quality of life associated with biologically
Intervention Model: Single Group Assignment, Primary Purpose: Treatment
Local Response in spatial reference to High Risk GTV (as identified by functional imaging)
3 months after treatment completion
Data Monitoring Committee: