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Microbubble Contrast Ultrasound and Transient Elastography Imaging of Early Breast Cancer

18 Years
80 Years
Not Enrolling
Ductal Carcinoma In-situ

Thank you

Trial Information

Microbubble Contrast Ultrasound and Transient Elastography Imaging of Early Breast Cancer

Women who have imaging findings suggestive of DCIS, who are having breast ultrasound and who
are candidates for surgery will be eligible. They will receive a contrast-enhanced breast
ultrasound after the intravenous injection of a microbubble contrast agent which will show
the microvascularity. A subset of women will also have ultrasound elastography performed of
the abnormality to evaluate its stiffness.

Inclusion Criteria:

- A woman with imaging signs suggesting a diagnosis of DCIS who is scheduled for
ultrasound and a biopsy is eligible for the study.

- At least 18 years of age

Exclusion Criteria:

- Pregnant or possibly pregnant or breast feeding

- Unable to provide informed consent

- Drug or multiple allergies

- Known cardiac shunts

- Known cardiac or chronic pulmonary disease

- Hypersensitivity to perflutren

Type of Study:


Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Evidence of the presence of angiogenic tumour vasculature in patients diagnosed with DCIS utilizing contrast enhanced ultrasound.

Outcome Time Frame:

The participant will be followed up till the results of the biopsy, an expected average of 3 months.

Safety Issue:


Principal Investigator

Roberta A Jong, FRCPC

Investigator Role:

Principal Investigator

Investigator Affiliation:

Sunnybrook Health Sciences Centre


Canada: Health Canada

Study ID:




Start Date:

September 2011

Completion Date:

September 2013

Related Keywords:

  • Ductal Carcinoma In-situ
  • Ductal Carcinoma In-situ
  • Contrast Ultrasound
  • Microinvasion
  • Elastography
  • Breast Neoplasms
  • Carcinoma
  • Carcinoma in Situ
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Ductal, Breast
  • Carcinoma, Ductal