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Time Course and Nature of Nutrient Sensing During Fasting in Humans

19 Years
29 Years
Not Enrolling
Nutrient Sensing During a Prolonged Fast

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Trial Information

Time Course and Nature of Nutrient Sensing During Fasting in Humans

Inclusion Criteria:

- Healthy males

- Age 19-29 years old

- Body mass index (BMI) 19-25 kg/m2

- Stable weight for the last 3 months

- Caucasian

- Fasting plasma glucose (FPG) < 6 mmol/L

- Well-controlled blood pressure (< 150/95 mmHg)

- Creatinine <100 umol/l

- Hb > 7.5 mmol/l

- Negative family history (first degree) of type 2 diabetes mellitus (DM2)

Exclusion Criteria:

- Use of medication known to affect glucose metabolism (for example prednisone) or
lipid metabolism

- Significant (chronic) disease

- Smoking (current)

- Alcohol consumption of more than 14 units per week at present or in the past

- Difficult accessible veins for insertion of an intravenous catheter

- Recent blood donation (within the last 3 months)

- Recent participation in other research projects (within the last 3 months),
participation in 2 or more projects in one year

- Rigorous exercise/sports 5 or more days a week

Type of Study:


Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Change in several proteins/ribonucleic acid (RNA) from muscle biopsies upon fasting

Outcome Time Frame:

1.5h, 4h, 10h, 24h

Safety Issue:


Principal Investigator

Hanno Pijl, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Leiden University Medical Center


Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:




Start Date:

February 2011

Completion Date:

March 2011

Related Keywords:

  • Nutrient Sensing During a Prolonged Fast
  • Set time points during 48 hours of fasting