Inclusion Criteria:

1. Age 18 years or older

2. Patients with refractory or relapsed acute leukemia unable to receive myeloablative
conditioning.

3. Patients with refractory or relapsed acute leukemia able to receive myeloablative
conditioning but with the following factors:

AML- 2 or more of the following: duration of CR1 < 6 months, poor cytogenetics,
circulating blasts, karnofsky < 90.

ALL- age > 40 or second and additional relapse, or 2 or more of the following: BM
blasts > 25%, age 18-39,first refractory relapse, donor CMV positive.

4. Patients with 2 matched siblings and donor age > 18 years old.

5. Patients with advanced multiple myeloma with life expectancy of less than 6 months
with standard therapy or transplantation.

6. Patients with advanced lymphoma with life expectancy of less than 6 months with
standard therapy or transplantation.

Exclusion Criteria:

1. Patient age < 18 years.

2. Donor age < 18 years.

3. Patients in remission or not fulfilling above disease criteria -