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Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis


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Papillary Thyroid Microcarcinoma

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Trial Information

Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis


Papillary thyroid carcinomas (PTCs) measuring 1.0 cm or less in diameter were defined as
papillary thyroid microcarcinomas (PTMCs) by the World Health Organization (WHO),
emphasizing on their benign behavior, probably of little clinical significance, which do not
affect patients' survival. However, some reported that PTMCs may have aggressive behavior,
can cause locoregional recurrences, cervical lymph node metastases, and even distant
metastases. But till now, the characteristics of PTMCs with early lateral neck node
metastasis were only reviewed and described by the clinicopathological parameters, and no
analysis of PTMCs by the gene level is available. In these study, we investigate the genetic
expressional alteration which influenced on the early lateral neck node metastasis in
thyroid papillary microcarcinoma.


Inclusion Criteria:



- age≥20 years old

- Conventional type papillary thyroid microcarcinoma (0.5cm≤tumor size≤1.0cm)

- group 1: no lymph node metastasis /group 2: with lateral neck node metastasis

Exclusion Criteria:

- tumor with capsular invasion (T3 tumor)

- distant metastasis

- combined underlying thyroiditis

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

mRNA expression pattern by microarray analysis

Outcome Description:

mRNA expression differences between papillary thyroid microcarcinoma without lateral neck node metastasis and the one with lateral neck node metastasis. (The outcome will be measured within 24-hour after surgical removement using papillary thyroid microcarcinoma tissue.)

Outcome Time Frame:

24-hour after surgical removement

Safety Issue:

No

Authority:

South Korea: Korea Food and Drug Administration (KFDA)

Study ID:

4-2011-0212

NCT ID:

NCT01384669

Start Date:

June 2011

Completion Date:

December 2013

Related Keywords:

  • Papillary Thyroid Microcarcinoma
  • Neoplasm Metastasis
  • Thyroid Diseases

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