Can Injection of Methylprednisoloneacetate 80 mg, in the Cavity After Mastectomy for Primary Breast Cancer, at the Time of Removal of the Drain, Prevent Seroma Formation?
After mastectomy, up to 90 % of patients develops seroma in the cavity. The treatment is
puncture, which is a small operation, but many patients have to come several times, and
there is a risk of infection. In some cases further treatment can be postponed.
Preventing seroma to develop would be an improvement in the treatment of breast cancer
patients operated with mastectomy.
An earlier study found that the seroma production was significant lower in the group who had
Prednison injected directly into the cavity.
In this study the patient are divided into two groups: patients who have mastectomy and
axillary dissection and patients who have mastectomy and Sentinel Node operation. Each group
are examined separately.
Using Prednison in patients after operation could be a potential risk, but correct injection
into the cavity will seldom give systemic side effects.
Observational Model: Case Control, Time Perspective: Prospective
number of punctures
1 month after surgery
Gro M Qvamme, MD
Denmark: Danish Dataprotection Agency