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Utility of XCL1 as a Prognostic Marker in Acute Lymphoblastic Leukemia

1 Year
Open (Enrolling)
Acute Lymphoblastic Leukemia

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Trial Information

Utility of XCL1 as a Prognostic Marker in Acute Lymphoblastic Leukemia

Each year approximately 256,000 children and adults around the world develop a form of
leukemia, and 209,000 died from it. Recently, some studies have evaluated the relationship
between the concentration of some cytokines and prognosis of acute lymphoblastic leukemia.
XCL1 is a lymphotactin that belongs to a cytokine subfamily called C or γ with only one
cysteine in the N-terminal residue. It has been found with significant expression of
receptor mRNA XCL1 (XCR1) in T and B lymphocytes and related to hematological neoplasms. For
these reasons, XCL1 could be a efficient marker of prognosis in patients with acute
lymphoblastic leukemia.

Inclusion Criteria:

Patients with newly diagnosed acute lymphoblastic leukemia .

Exclusion Criteria:

- Patients with prior treatment with chemotherapeutic agents.

- Patients treated with immunosuppressants.

- Patients under 12 months old.

- Patients with a diagnosis or history of autoimmune diseases.

- Patients with a diagnosis or history of immunosuppressive diseases.

- Patients who do not agree to sign a Letter of Informed Consent.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Number of patients with poor prognosis and high levels of XCL1

Outcome Description:

Number of patients with high levels of XCL1, expression of its receptor and other cytokines.

Outcome Time Frame:

3 months

Safety Issue:


Principal Investigator

Cesar H Gutierrez Aguirre, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Hospital Universitario Dr. Jose E. Gonzalez UANL


Mexico: Ethics Committee

Study ID:




Start Date:

November 2010

Completion Date:

January 2013

Related Keywords:

  • Acute Lymphoblastic Leukemia
  • ALL
  • XCL1
  • Cytokines
  • Prognosis
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma