Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Infection in Elective Surgery
A prospective, randomized study was performed between January and December 2010. Patient
inclusion criteria were a diagnosis of colorectal neoplasms and plans to undergo an elective
curative surgery. Patients were divided into 2 groups: Group 1 (intra-abdominal irrigation
with normal saline) and Group 2 (intraperitoneal irrigation with a solution of 240 mg
gentamicin and 600 mg clindamycin). The occurrence of wound infections and intra-abdominal
abscesses were investigated. Following the anastomosis, a microbiological sample of the
peritoneal surface was obtained (sample 1). A second sample was collected following an
irrigation with normal saline (sample 2). Finally, the peritoneal cavity was irrigated with
a gentamicin-clindamycin solution and a third sample was obtained (sample 3).
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Surgical site infection
Intra-abdominal abscess and wound infection will be investigated during the first 30 days after colorectal surgery
30 days
Yes
Spain: Ethics Committee
jruiztovar
NCT01378832
January 2010
December 2010
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