Inclusion Criteria

- INCLUSION CRITERIA:

- Men greater than 18 years of age

- Organ confined clinical T1C or clinical T2a prostate cancer that is visualized on MR
imaging

- Prostate cancer is diagnosed by transrectal ultrasound guided standard 12 core biopsy
or MR image guided biopsies

- Gleason Score less than or equal to 7 (3+4), less than or equal to 3 cores
positive in a standard 12 core biopsy or less than or equal to 4 cores positive
on MR image guided biopsy where in 2 cores are taken from each of the two MRI
target lesions

- If the standard biopsy cores are positive, they must be from the same location
in the prostate as MR Lesion was biopsied and proven to be cancer. (Left /
Right, Base, Mid Gland, Apex).

- MRI obtained within 6 months of ablation

- Metastatic Disease work up as per NCCN guidelines (www.nccn.org) - Bone scan
indicated to r/o metastatic disease if [clinical T1 and PSA > 20 or T2 and PSA >
10]

- PSA less than or equal to 15 ng/ml or PSA density less than or equal to 0.15 ng/ml(2)
in patients with a PSA > 15 ng/ml

- The patient has given written informed consent after the nature of the study and
alternative treatment options have been explained.

- Patients who present with local recurrence or residual tumor after prostate cancer
treatment which is visible on MRI.

EXCLUSION CRITERIA:

- The presence of 3 or more MR Visible lesions positive on biopsy

- The presence of extra capsular, seminal vesical invasion or metastatic disease.

- Patient is unable to tolerate MRI (foreign body, i.e. pacemaker or other implanted
device; claustrophobia; inability to tolerate rectal coil; etc )

- Patient with inability to follow up

- Acute urinary tract infection

- Lower urinary tract symptoms defined by a International Prostate symptom score (IPSS)
> 20

- Patients with renal insufficiency with an estimated glomerular filtration (EGF) < =
30 are excluded, due to they will not be able to undergo gadolinium enhance MRI.

- Patients with Uncontrolled Coagulopathies who are at increased risk of bleeding.

- Altered mental status preventing consent or answering questions during conduct of the
trial will be excluded for safety purposes.

- Other serious illnesses according to the PI: involving the cardiac, respiratory, CNS,
renal or hepatic organ systems, which would preclude study completion or impede the
determination of causality of any complications experienced during the conduct of
this study.

- A Standard 12 core biopsy positive for cancer with no corresponding MR targeted
lesion positive for cancer in the same general region of the prostate (Right Apex,
Right Mid Gland, Right Base, Left Base, Left Mid Gland, Left Apex)