Racial Disparity in Barrett's Esophagus
The goal of the proposed research is to investigate the molecular mechanisms of racial
disparity in Barrett's esophagus, the premalignant lesion of esophageal adenocarcinoma.
Specifically, the investigators hypothesize that environmental factors, genetic factors, and
potentially gene environment interactions play crucial roles in the observed racial
disparity in developing Barrett's esophagus.
Participants: Patients aged 18-80 presenting at the Gastrointestinal (Gl) Endoscopy Clinic
at UNC-Chapel Hill for elective upper endoscopy with a primary or secondary indication of
Procedures (methods): Endoscopic biopsy, pH impedance and sampling of gastric secretions
will be performed according to our standard protocol. A series of questionnaires assessing
demographics, environmental exposure (e.g., smoking, drinking), markers of socioeconomic
status (SES), body measurement, previous health history, and gastroesophageal reflux disease
(GERD) symptomatology will be administered to our subjects.
Observational Model: Case Control, Time Perspective: Cross-Sectional
To examine the association between BE and environmental factors
Odds ratios (ORs) and 95% confidence intervals (CI) will be used to estimate the association between gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) among Caucasian Americans and African Americans, separately, in relation to patterns of the exposures of interest (tobacco use, alcohol consumption, fruit and vegetable intake and other dietary measures, no NSAID use, and various measures of SES), with adjustments made for the frequency matching factors, age at reference (date of diagnosis for cases and date of identification for controls) and sex.
Enrollment (day 1)
Nicholas Shaheen, MD, MPH
University of North Carolina, Chapel Hill
United States: Institutional Review Board
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