In Vivo Molecular Imaging of Epidermal Growth Factor Receptor in Patients With Colorectal Neoplasia Using Confocal Laser Endomicroscopy
Various kinds of tumor markers have been shown to be over-expressed in colorectal cancer,
including epidermal growth factor receptor(EGFR). The conventional detection method of EGFR
expression in colorectal neoplasia is immunohistochemistry which is time-consuming, and the
immunoreactivity can be affected by storage and fixation of tissues. Confocal laser
endomicrosopy is a newly developed device which could identify the cellular and subcellular
structures clearly with the magnification at×1000, making it possible to explore the
physiological and pathological molecular mechanism of the gastrointestinal tract. So the
study aims to achieve molecular imaging of EGFR in colorectal neoplasia in vivo using
confocal laser endomicroscopy.
Time Perspective: Prospective
Yanqing Li, PhD. MD.
Department of Gastroenterology, Qilu Hospital
China: Ministry of Health