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In Vivo Molecular Imaging of Epidermal Growth Factor Receptor in Patients With Colorectal Neoplasia Using Confocal Laser Endomicroscopy


N/A
18 Years
80 Years
Not Enrolling
Both
Colorectal Cancer, Colorectal Adenoma

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Trial Information

In Vivo Molecular Imaging of Epidermal Growth Factor Receptor in Patients With Colorectal Neoplasia Using Confocal Laser Endomicroscopy


Various kinds of tumor markers have been shown to be over-expressed in colorectal cancer,
including epidermal growth factor receptor(EGFR). The conventional detection method of EGFR
expression in colorectal neoplasia is immunohistochemistry which is time-consuming, and the
immunoreactivity can be affected by storage and fixation of tissues. Confocal laser
endomicrosopy is a newly developed device which could identify the cellular and subcellular
structures clearly with the magnification at×1000, making it possible to explore the
physiological and pathological molecular mechanism of the gastrointestinal tract. So the
study aims to achieve molecular imaging of EGFR in colorectal neoplasia in vivo using
confocal laser endomicroscopy.

Inclusion Criteria


Inclusion Criteria：

●Patients known to have large polypoid lesions in colon or rectum from previous
examinations from outpatients and inpatients at Qilu Hospital were enrolled into the study

Exclusion Criteria:

- Patients who are allergic to fluorescein sodium

- Patients with impaired cardiac, liver or renal function

- Patients who are unwilling to sign or give the informed consent form

- Patients with giant tumors or obvious GI tract bleeding which make it hard or
impossible to observe the lesions

- Patients with coagulopathy

- Patients with pregnancy or breastfeeding

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Principal Investigator

Yanqing Li, PhD. MD.

Investigator Role:

Study Director

Investigator Affiliation:

Department of Gastroenterology, Qilu Hospital

Authority:

China: Ministry of Health

Study ID:

2011SDU-QILU-G01

NCT ID:

NCT01372189

Start Date:

January 2011

Completion Date:

July 2011

Related Keywords:

  • Colorectal Cancer
  • Colorectal Adenoma
  • molecular imaging
  • epidermal growth factor receptor
  • colorectal neoplasia
  • confocal laser endomicroscopy
  • Adenoma
  • Neoplasms
  • Colorectal Neoplasms

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