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Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7 Antigen


N/A
18 Years
80 Years
Not Enrolling
Both
Gastric Cancer

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Trial Information

Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7 Antigen


Gastric cancer remains the world's second leading cause of cancer-related death. Improved
prognosis essentially depend on earlier diagnosis. Gastric monoclonal antibody MG7 has been
validated as a specific antibody in gastric cancerous tissue. Conventional evaluation of MG7
antigen expression is immunohistochemistry, which is time-consuming, and the
immunoreactivity can be affected by storage and fixation of tissue. Confocal laser
endomicrosopy enables visualization of the cellular and subcellular structures in vivo. Thus
this study aims to achieve molecular imaging of MG7 antigen in gastric cancer in vivo using
confocal laser endomicroscopy.


Inclusion Criteria:



- patients with endoscopically diagnosed gastric cancer

Exclusion Criteria:

- Patients who are allergic to fluorescein sodium

- Patients who are unwilling to sign or give the informed consent form

- Patients with giant tumors or obvious GI tract bleeding which make it hard or
impossible to observe the lesions

- Patients with impaired cardiac, liver or renal function

- Patients with coagulopathy

- Patients with pregnancy or breastfeeding

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Principal Investigator

Yanqing Li, MD, PhD

Investigator Role:

Study Director

Investigator Affiliation:

Department of Gastroenterology, Qilu Hospital

Authority:

China: Ministry of Health

Study ID:

2011SDU-QILU-G02

NCT ID:

NCT01366586

Start Date:

May 2011

Completion Date:

July 2011

Related Keywords:

  • Gastric Cancer
  • Stomach Neoplasms

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