Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7 Antigen
Gastric cancer remains the world's second leading cause of cancer-related death. Improved
prognosis essentially depend on earlier diagnosis. Gastric monoclonal antibody MG7 has been
validated as a specific antibody in gastric cancerous tissue. Conventional evaluation of MG7
antigen expression is immunohistochemistry, which is time-consuming, and the
immunoreactivity can be affected by storage and fixation of tissue. Confocal laser
endomicrosopy enables visualization of the cellular and subcellular structures in vivo. Thus
this study aims to achieve molecular imaging of MG7 antigen in gastric cancer in vivo using
confocal laser endomicroscopy.
Observational
Time Perspective: Prospective
Yanqing Li, MD, PhD
Study Director
Department of Gastroenterology, Qilu Hospital
China: Ministry of Health
2011SDU-QILU-G02
NCT01366586
May 2011
July 2011
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