Early Intervention With Exercise in Critically Ill Patients With Sepsis: a Randomized Controlled Trial
This study will investigate the effects of an early targeted rehabilitation program on
inflammatory markers and muscle mass in patients with sepsis syndromes in intensive care.
The Primary Hypothesis is that an early targeted rehabilitation ICU patients with sepsis
syndromes over 7 days will Prevent loss of lean muscle mass by within 7 days of recruitment
to the study. Decrease pro-inflammatory and increase anti-inflammatory cytokines within 7
days of recruitment to the study.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Fat free mass ie muscle mass (lean tissue)
Fat free mass will be measured by Multi-Frequency Bioelectrical Impedance Spectroscopy (BIS) (ImpediMed SFB7, ImpediMed Ltd, Brisbane, Australia).
Change from baseline to one week, then change from baseline to two weeks
Australia: Human Research Ethics Committee