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Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors

18 Years
69 Years
Open (Enrolling)
Severe Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Myeloproliferative Syndromes, Chronic Myelogenous Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Large Granulocytic Leukemia

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Trial Information

Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors

Inclusion Criteria:

- > 18 years of Age

- < 70 years

- ECOG performance status 0, 1 or 2

- Left Ventricular Ejection Fraction > 30%

- Creatinine clearance > 40ml/min

- Transaminases < 2X normal

- Total bilirubin < 2X normal

- HIV seronegativity

- Weight < 70kg for cord blood transplantation

Exclusion Criteria:

- Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at
HLA-A, B, C or DR

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Bone Marrow and Peripheral Blood Chimerism

Outcome Description:

Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.

Outcome Time Frame:

30 days post-transplant

Safety Issue:


Principal Investigator

Jeffrey W. Andrey, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Scripps Clinic Medical Group


United States: Institutional Review Board

Study ID:




Start Date:

March 2005

Completion Date:

January 2023

Related Keywords:

  • Severe Aplastic Anemia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Acute Myelogenous Leukemia
  • Acute Lymphoblastic Leukemia
  • Myelodysplastic Syndromes
  • Myeloproliferative Syndromes
  • Chronic Myelogenous Leukemia
  • Hodgkin's Lymphoma
  • Non-Hodgkin's Lymphoma
  • Multiple Myeloma
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Large Granulocytic Leukemia
  • Transplant
  • Allogeneic
  • Allogeneic transplant
  • Unrelated donor transplant
  • MUD
  • HSCT
  • Stem cell transplant
  • Anemia
  • Anemia, Aplastic
  • Hemoglobinuria
  • Hodgkin Disease
  • Leukemia
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Hemoglobinuria, Paroxysmal
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Myelodysplastic Syndromes
  • Preleukemia
  • Myeloproliferative Disorders



Scripps Green Hospital La Jolla, California  92037