Absorption of Anti-tuberculosis Drugs and Its Effect to Treatment Response in Gastrectomized Patients
Gastrectomy is a well-known risk factor for TB. Also, there were some reports about
malabsorption of anti-TB drugs in the gastrectomized patients. However, pharmacokinetics of
recently used first line anti-TB drugs in the gastrectomized patients have not been well
evaluated simultaneously. Therefore, the investigators aim to evaluate the effect of
gastrectomy on pharmacokinetic profile of first-line anti-TB drugs in patients with
pulmonary TB through this study.
Observational Model: Case Control, Time Perspective: Prospective
The change in the maximum concentration (Cmax) of first-line TB drugs
Before and 1, 2, 4, 6 and 8 hours after dosing
Hee Seok Lee, M.D.
National Cancer Center
Korea: Institutional Review Board