Inclusion Criteria:
- aged from 18 to 70 years old, male or female;
- histologically or cytologically proven advanced malignant solid tumors;
- cancer patients after conventional treatment failure and lack of effective treatment,
or patients refusing effective treatment of existing practices;
- patients receiving the last treatment (chemotherapy, radiotherapy, biological
therapy, targeted therapy, or other study drugs) for at least 4 weeks;
- expected survival time>3 months;
- ECOG score 0-1
Exclusion Criteria:
- viral activity in patients
- allergic to drugs or excipients;
- hypersensitivity to paclitaxel injection patients;
- HIV antibody positive, or suffering from other acquired and congenital immune
deficiency disease, or history of organ transplantation;
- neutrophil count <1.5 × 109 / L, platelets <100 × 109 / L, or hemoglobin <90g / L;
- normal serum creatinine higher than 1.5 times the upper limit of reference range or
the muscle of liver clearance <60ml/min;
- no case of liver ALT or AST> 2.5 times the upper limit of normal, or liver metastases
than normal under the ALT or AST 5 times upper limit of reference range;
- fever or body temperature above 38 ℃ can be clinically significant impact on clinical
trials of active infection;
- medications failed to control hypertension (systolic pressure is over 160 mmHg or
diastolic pressure over 100mmHg);
- significant cardiovascular abnormalities (such as myocardial infarction, superior
vena cava syndrome), or clinically significant arrhythmias (such as long QT syndrome,
Corrected QTc not be measured or ≧ 480 ms);
- calcium, potassium, magnesium ions below the lower limit of normal;
- > I-level peripheral neuropathy
- Prior to the toxicity of anticancer therapy has not been restored or not from the
surgery before full recovery;
- bone metastases for the primary lesion of palliative radiotherapy;
- any clinical problems can not control (such as the serious mental, neurological,
cardiovascular, respiratory and other diseases);
- a tumor metastasis, or a variety of mental disorders center; no history of asthma;
- pregnancy or breast-feeding women