Tissue Characterisation Using Ultrasound Based Strain Imaging(Elastography)Examining Lesions in the Gastrointestinal Wall, Adjacent Lymph Nodes and Pancreatic Lesions
The purpose of this study is to use endoscopic ultrasonography (EUS) with strain based
elastography to identify strain traits separating malignant from benign lesions. We are
registering feasibility of endoscopic strain imaging and compare diagnostic accuracy of EUS
+ elastography with previous data on EUS alone.
- Group 1: Focal subepithelial lesions in esophageal, ventricular or duodenal wall
discovered by endoscopy or other imaging modality.
- Group 2: Pancreatic lesion discovered by other imaging modality.
- Group 3: Mediastinal or retroperitoneal lymph node or tumor discovered by other imaging
Histology of lesions should not be known at the time of examination. EUS elastography
findings are evaluated shortly after the examination and categorised by different methods;
categorical score, VAS, Strain Ratio. The result is then compared to histology or cytology
results. Patients who do not undergo tissue sampling are followed up to discover disease
Observational Model: Case-Only, Time Perspective: Prospective
Malignant or benign lesion
Imaged lesions are sampled, surgically removed or followed up > 6 months to conclude on their nature. Images are evaluated, measured and categorised shortly after examination and compared to histological, cytological or follow up result. Elastography results do not interfere with surgical or oncological treatment planning in this study.
Jan 2007 - September 2011 + 6 months( if no tissue sample)(4 years)
Lars Birger Nesje, MD, PhD
University of Bergen
Norway: Norwegian Social Science Data Services