Combined Transplantation of Unmanipulated Haploidentical and a SingleCord Blood Unit for Patients With Hematologic Malignancies
N/A
18 Years
N/A
18 Years
N/A
Not Enrolling
Both
Hematological Disease
Both
Hematological Disease
Trial Information
Combined Transplantation of Unmanipulated Haploidentical and a SingleCord Blood Unit for Patients With Hematologic Malignancies
Inclusion Criteria:
- Relapsed or refractory acute leukemia (myeloid or lymphoid)
- Acute leukemia in first remission at high-risk for recurrence
- Chronic myelogenous leukemia in accelerated phase or blast-crisis
- Chronic myelogenous leukemia in chronic phase
- Recurrent or refractory malignant lymphoma or Hodgkin lymphoma
- Chronic lymphocytic leukemia, relapsed or with poor prognostic features
- Multiple myeloma
- Myelodysplastic syndrome
- Chronic myeloproliferative disease
- Hemoglobinopathies
- Aplastic anemia
Exclusion Criteria:
- Zubrod performance status > 2
- Life expectancy is severely limited by concomitant illness
- Patients with severely decreased LVEF or impaired pulmonary function tests
- Estimated Creatinine Clearance <50 ml/min
- Serum bilirubin> 2.0 mg/dl or SGPT >3 x upper limit of normal
- Evidence of chronic active hepatitis or cirrhosis
- HIV-positive
- Patient is pregnant
- Patient or guardian not able to sign informed consent
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Cord Blood Engraftment
Outcome Description:
Detectable cord blood engraftment should be present by day 100 in at least 50% of patients.
Outcome Time Frame:
100 days
Safety Issue:
No
Principal Investigator
Andrew Artz, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Chicago
Authority:
United States: Institutional Review Board
Study ID:
10-020-B
NCT ID:
NCT01359254
Start Date:
April 2010
Completion Date:
June 2012
Related Keywords:
- Hematological Disease
- Hematologic Diseases
Name | Location |
|---|---|
| University of Chicago | Chicago, Illinois 60637 |
