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Investigation of DICER1 in Cystic Nephroma and Cystic Partially Differentiated Nephroblastoma


N/A
N/A
N/A
Open (Enrolling)
Both
Brain and Central Nervous System Tumors, Hereditary Wilms Tumor, Kidney Cancer, Liver Cancer, Neuroblastoma, Pleuropulmonary Blastoma, Sarcoma

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Trial Information

Investigation of DICER1 in Cystic Nephroma and Cystic Partially Differentiated Nephroblastoma


OBJECTIVES:

- To determine if DICER1 mutations contribute to tumor pathogenesis in cystic nephromas
and cystic partially differentiated nephroblastomas outside of families with
pleuropulmonary blastoma (PPB) syndrome.

OUTLINE: Archived DNA samples are analyzed for DICER1 mutation by qPCR and directly
sequenced using BigDye Terminator chemistry. Results are then compared against the single
nucleotide polymorphism (SNP) database.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of pleuropulmonary blastoma syndrome

- Normal tissue samples, if available

- Parental and sibling DNA samples, if available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Relationship between DICER1 mutations and tumor pathogenesis in cystic nephromas and cystic partially differentiated nephroblastomas outside of families with PPB nephroblastomas

Safety Issue:

No

Principal Investigator

Dana A. Hill, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Research Institute

Authority:

United States: Federal Government

Study ID:

CDR0000700282

NCT ID:

NCT01353300

Start Date:

May 2011

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • Hereditary Wilms Tumor
  • Kidney Cancer
  • Liver Cancer
  • Neuroblastoma
  • Pleuropulmonary Blastoma
  • Sarcoma
  • embryonal childhood rhabdomyosarcoma
  • cystic nephroma
  • neuroblastoma
  • childhood medulloblastoma
  • childhood hepatoblastoma
  • stromal predominant Wilms tumor
  • hereditary Wilms tumor
  • pleuropulmonary blastoma
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Liver Neoplasms
  • Wilms Tumor
  • Nervous System Neoplasms
  • Neuroblastoma
  • Central Nervous System Neoplasms
  • Sarcoma
  • Pulmonary Blastoma

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