Investigation of DICER1 in Cystic Nephroma and Cystic Partially Differentiated Nephroblastoma
OBJECTIVES:
- To determine if DICER1 mutations contribute to tumor pathogenesis in cystic nephromas
and cystic partially differentiated nephroblastomas outside of families with
pleuropulmonary blastoma (PPB) syndrome.
OUTLINE: Archived DNA samples are analyzed for DICER1 mutation by qPCR and directly
sequenced using BigDye Terminator chemistry. Results are then compared against the single
nucleotide polymorphism (SNP) database.
Observational
N/A
Relationship between DICER1 mutations and tumor pathogenesis in cystic nephromas and cystic partially differentiated nephroblastomas outside of families with PPB nephroblastomas
No
Dana A. Hill, MD
Principal Investigator
Children's Research Institute
United States: Federal Government
CDR0000700282
NCT01353300
May 2011
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