Inclusion Criteria:

- Unequivocal pathologic diagnosis of AML (≥ 20% blasts in the bone marrow based on WHO
criteria) excluding: i) acute promyelocytic leukemia t(15;17)(q22;q12); PML-RARA;
ii)acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNXT1; iii) acute myeloid
leukemia with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBFB-MYH11.

- AML patients with an antecedent hematologic disorder or myelodysplastic syndrome
(MDS)are eligible for treatment on this trial provided that they have not received
prior treatment with decitabine or prior cytotoxic treatment for AML.

- AML patients with therapy-related myeloid neoplasms (t-MN) are eligible if they have
not received chemotherapy (not including hormonal therapy) for their primary
malignancy or disorder for >6 months.

- Age ≥ 60 years.

- Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria:

- Prior treatment with decitabine

- Prior treatment with plerixafor

- Ongoing treatment for another malignancy.

- Patients with good-risk molecular or cytogenetics features

- Patient has a medical condition or illness considered by the investigator to
constitute an unwarranted high risk for investigational drug treatment.

- Patient has a psychiatric disorder or altered mental status that would preclude
understanding of the informed consent process and/or completion of the necessary
studies.

- Patient has an inability or unwillingness, in the opinion of the investigator, to
comply with the protocol requirements.