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Expression Levels of RNA-induced Silencing Complex (RISC) Components TARBP1, TARBP2, Argonaute-1, Argonaute-2, PACT and Microprocessor Complex Component DGCR8 in Epithelial Skin Cancer


N/A
18 Years
N/A
Not Enrolling
Both
Skin Cancer

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Trial Information

Expression Levels of RNA-induced Silencing Complex (RISC) Components TARBP1, TARBP2, Argonaute-1, Argonaute-2, PACT and Microprocessor Complex Component DGCR8 in Epithelial Skin Cancer


Patients with premalignant actinic keratoses, basal cell carcinomas and squamous cell
carcinomas were included in the study. Punch biopsies were harvested from the center of the
tumors, from sites of healthy skin and a healthy control group. DGCR8, TARBP1, TARBP2,
argonaute-1, argonaute-2 and PACT mRNA expression levels were detected by quantitative
real-time reverse transcriptase polymerase chain reaction.


Inclusion Criteria:



- epithelial skin cancer

Exclusion Criteria:

- other known previous malignancies

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Principal Investigator

Falk G Bechara, PD Dr.

Investigator Role:

Study Director

Investigator Affiliation:

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum

Authority:

Germany: Ethics Commission

Study ID:

1-Sand

NCT ID:

NCT01345760

Start Date:

July 2008

Completion Date:

February 2011

Related Keywords:

  • Skin Cancer
  • Basal Cell Carcinoma
  • Squamous Cell Carcinoma
  • Actinic Keratosis
  • microRNA
  • Dicer
  • Drosha
  • RISC
  • microprocessor complex
  • Argonaute
  • DGCR8
  • TARBP
  • Skin Neoplasms

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