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Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

50 Years
75 Years
Open (Enrolling)
Colon Cancer

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Trial Information

Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Inclusion Criteria

Inclusion criteria:

- scheduled for screening colonoscopy

- off NSAID or aspirin therapy in accordance with OHSU endoscopy clinic guidelines

- INR 0.90-1.20

- hemoglobin ≥ 13.5 (men) or 12.0 (women)

- platelets ≥100,000/μL

- Chem screen results within normal limits

- negative (serum or urine) pregnancy test done ≤7 days prior to colonoscopy for women
of childbearing potential only

- ASA performance status <2

Exclusion criteria:

- history of colon cancer or adenomatous polyps

- current smoker

- medical history of chronic obstructive pulmonary disease

- current oral steroid therapy

- current therapy with valproate or other pharmacological drugs associated with HDAC

- use of oral antibiotics within 3 months prior to entry into study

- significant active medical illness which in the opinion of the investigator would
preclude collection/interpretation of colon tissue

- diagnosis of hemophilia, van Willebrand's disease or other bleeding disorder

- use of warfarin or other blood thinning agents

- inflammatory bowel disease.

Type of Study:


Study Design:

Time Perspective: Prospective

Outcome Measure:

Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites

Outcome Time Frame:

At colonoscopy (day 1)

Safety Issue:


Principal Investigator

Rod Dashwood, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Oregon State University


United States: Institutional Review Board

Study ID:

P01 CA090890



Start Date:

January 2012

Completion Date:

December 2014

Related Keywords:

  • Colon Cancer
  • Colon cancer
  • Prevention
  • Cruciferous vegetables
  • Histone status
  • Colonic Neoplasms



Oregon Health & Science University Portland, Oregon  97201