A Randomized Controlled Crossover Trial of Two Different Central Venous Catheter Flushing Schemes in Pediatric Hematology and Oncology Patients in Alberta, Canada
Tunneled central venous catheters (CVCs) are now used routinely in pediatric hematology and
oncology patients. Flushing with heparin solution is routinely recommended to prevent
occlusion of long term CVCs, although the concentration of heparin used, and frequency of
its use varies between centres. Once weekly Normal saline is also used successfully in some
pediatric enters. There is little evidence to support one method over the other.
The investigators have designed a randomised crossover trial to directly compare once weekly
Normal saline flushing with 3 times per week 10U/ml heparin flushing, to determine whether
Normal saline is not inferior to heparin.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Martin A Campbell, MBBS FRACP
Alberta Children's Hospital
Canada: Ethics Review Committee